Yes. Most, but not all, residential mortgages are sold by the originating lenders to Fannie Mae and Freddie Mac. The GSE’s have long-stated that unless the “seller” of the loan is an approved e-Note lender, they will insist that the promissory note be delivered in wet-signed form. For lenders that warehouse their loans and do not seek to sell them to the GSEs, they may allow for the loan documents, including the note, to be signed digitally.
Before proceeding with an all-digital loan closing, confirm with the lender that it will accept an electronically signed note and other loan documents.